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Press release

Please fill in this form and return it to graduateschoolhealth@au.dk in Word format no later than three weeks prior to your defence.

Basic information

Name: Anne Sophie Lind Helligsø Email: aslindfischer@clin.au.dk Phone: +45 60918867

Department of: Clinical Medicine

Main supervisor: Professor, Consultant, MD, DMSc Jeanette Falck Winther, Department of Clinical Medicine, Faculty of Health, Aarhus University and Childhood Cancer Research Group, Danish Cancer Society Research Center, Denmark and Aarhus University Hospital, Denmark

Title of dissertation: Late effects after treatment for childhood brain tumor

Date for defence: 03.06.2022 at (time of day): 14:15 Place: Aarhus University Hospital Press release (Danish)

Senfølger efter behandling af hjernetumor i barndommen

I et nyt ph.d.-projekt fra Aarhus Universitet, Health undersøges senfølger hos overlevere af en

hjernetumor diagnosticeret i barndommen. Projektet er gennemført af Anne Sophie Lind Helligsø, der forsvarer det d. 3/6 2022.

Hvert år diagnosticeres omkring 40–50 børn med en hjernetumor i Danmark. Behandlingen består af en kombination af kirurgi, kemoterapi og bestråling. Der er sket store fremskridt i behandlingen over de seneste årtier, og i dag overlever omkring 75% af børnene. Selvom overlevelsen er stigende får disse børn ofte en lang række senfølger i årene efter endt kræftbehandling. Særligt strålebehandling af hjernen er kendt for at give mange senfølger herunder kognitive udfordringer såsom

indlæringsvanskeligheder og hukommelsesproblemer – alle senfølger, der kan påvirke børnenes livskvalitet.

I dette ph.d.-studie undersøges incidens og overlevelse af en hjernetumor samt senfølger såsom søvnsygdomme, kognitive udfordringer og livskvalitet.

Forsvaret af ph.d.-projektet er offentligt og finder sted den 3/6 2022 kl. 14.15 i Auditorium J116-113, Aarhus Universitets Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N. Titlen på projektet er

”Late effects after treatment for childhood brain tumor”. Yderligere oplysninger kontakt: Læge, Ph.d.- studerende Anne Sophie Lind Helligsø, e-mail: aslindfischer@clin.au.dk, tlf. 60918867.

Bedømmelsesudvalg:

- Professor Morten Høyer, Danmark - Professor Klas Blomgren, Sverige

- Associate Professor, Astrid Marie Sehested, Danmark Press release (English)

Late effects after treatment for childhood brain tumor

In this PhD project, late effects after treatment for a brain tumor in childhood were investigated. The project was carried out by Anne Sophie Lind Helligsø, who is defending her dissertation on 3/6 2022.

Every year around 40–50 children are diagnosed with a brain tumor in childhood. Treatment consists of a combination of surgery, chemotherapy and radiation. During the past decades, great progress in the treatment of a childhood braintumor has contributed to an improved survival reaching 75%.

Despite an improved survival, these children face late effects years later. Especially radiation is known

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to cause late effects such as neurocognitive impairment e.g., learning difficulties and memory problems – all late effects which might affect quality of life.

The defence is public and takes place on 3/6 2022 at 2:15 pm in J116-113, Aarhus University Hospital, Palle Juul-Jensens Boulevard 99, 8200 Aarhus N. The title of the project is "Late effects after

treatment for childhood brain tumor". For more information, please contact MD, PhD student Anne Sophie Lind Helligsø, email: aslindfischer@clin.au.dk, Phone +4560918867.

Assessment committee:

- Professor Morten Høyer, Denmark - Professor Klas Blomgren, Sweden

- Associate Professor, Astrid Marie Sehested, Denmark

Permission

By sending in this form:

 I hereby grant permission to publish the above Danish and English press releases.

 I confirm that I have been informed that any applicable inventions shall be treated confidentially and shall under no circumstances whatsoever be published, presented or mentioned prior to submission of a patent application, and that I have an obligation to inform my head of department and the university’s Patents Committee if I believe I have made an invention in connection with my work. I also confirm that I am not aware that publication violates any other possible holders of a copyright.

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